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Xymogen MitoPrime vs Orthomolecular MitoCore

MitoPrime has L-ergothioneine - a naturally occurring amino acid derivative that acts as a powerful antioxidant and cytoprotectant in the body. It is produced by certain microorganisms and fungi, such as filamentous fungi and actinobacteria. L-ergothioneine is not synthesized by the human body and must be obtained from dietary sources or supplementation.


Here are some key points about L-ergothioneine:


Antioxidant Activity: L-ergothioneine functions as an antioxidant, which means it helps neutralize harmful free radicals in the body. Free radicals are unstable molecules that can damage cells and contribute to various health issues, including aging and chronic diseases.


Cytoprotective Effects: L-ergothioneine also has cytoprotective properties, meaning it helps protect cells from damage and supports their optimal function. It has been shown to help protect mitochondria, the energy-producing organelles within cells, from oxidative stress and improve their overall efficiency.


Multiple Health Benefits: L-ergothioneine has been associated with several health benefits. Studies suggest that it may have anti-inflammatory properties, promote cardiovascular health, support cognitive function, enhance immune function, and protect against oxidative damage in various tissues and organs.


Proprietary Fermentation-based Method: MitoPrime®, features a concentrated form of L-ergothioneine produced through a proprietary fermentation-based method. This method likely involves the cultivation of specific microorganisms or fungi capable of synthesizing L-ergothioneine in a controlled fermentation process.

OrthoMolecular MitoCore also recharges cellular energy production, supports immune function, increases antioxidant protection, and supports detoxification capacity.



MitoCORE® boosts mitochondrial reserves and recharge cellular energy production. MitoCORE® includes the powerful antioxidant trio of alpha lipoic acid, N-acetyl cysteine and acetyl L-carnitine, all shown to recharge cellular energy production and the primary cellular antioxidant pools of vitamins E, C and glutathione. MitoCORE® also includes key micronutrients and phytonutrients, including green tea, broccoli seed extract and resveratrol, to protect the mitochondria and continually renew the cycle of energy production.

I asked Chat.AI for some help in deciding ‘what is what’ on MitoPrime vs MitoCore. Here is the response.


Alpha-lipoic acid, N-acetyl cysteine (NAC), acetyl-L-carnitine, and L-ergothioneine are all dietary supplements that have been studied for their potential health benefits. While they share some similarities, each compound has distinct mechanisms of action and effects in the body. Here's an overview of their relationships:

Alpha-lipoic acid: Alpha-lipoic acid (ALA) is a potent antioxidant that can be synthesized in small amounts by the body. It plays a role in cellular energy production and has both water- and fat-soluble properties, allowing it to function in various bodily compartments. ALA can regenerate other antioxidants like vitamins C and E, helping to combat oxidative stress. While ALA and L-ergothioneine are both antioxidants, they have different chemical structures and mechanisms of action.


N-acetyl cysteine (NAC): NAC is a modified form of the amino acid cysteine and is known for its ability to boost cellular levels of glutathione, one of the body's most potent antioxidants. NAC also has mucolytic properties, meaning it can help break down and thin mucus. While both L-ergothioneine and NAC have antioxidant properties, NAC primarily functions by supporting glutathione production, while L-ergothioneine acts as a direct antioxidant.


Acetyl-L-carnitine: Acetyl-L-carnitine (ALCAR) is an amino acid derivative that plays a role in energy metabolism. It helps transport fatty acids into the mitochondria, where they can be used for energy production. ALCAR has been studied for its potential benefits in cognitive function, mood regulation, and supporting mitochondrial health. While ALCAR and L-ergothioneine both have implications for mitochondrial function, they have distinct mechanisms of action and different effects on cellular metabolism.

L-ergothioneine: As mentioned earlier, L-ergothioneine is an amino acid derivative that acts as an antioxidant and cytoprotectant. It has been studied for its potential benefits in combating oxidative stress, supporting cellular health, and protecting against various diseases and age-related conditions. L-ergothioneine has unique properties and mechanisms of action compared to the other compounds mentioned.

While there may be some overlap in their effects on cellular health and antioxidant activity, each of these compounds acts through different pathways and may have distinct benefits in the body. I always find individual responses to supplements vary, and again I would advise a trial of the two separately and together. We can measure your Phase Angel every 3-6 weeks and see which influences the cell membranes more positively.

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